There are 103 âminorâ melatonin drug interactions. Melatonin may not always be needed for westbound travel. Spacing out the two will help. When youâre taking a hormone â hormonal changes are bound to happen. However, this could be far more serious than you think. Taking antibioticsâespecially those in the tetracycline familyâalong with iron supplements can dampen the effects of the antibiotics, making them less likely to work, Dr. Glatter says. Antibiotics and iron. Minor Interactions. Find everything you need to know about melatonin (Melatonin Time Release), including what it is used for, warnings, reviews, side effects, and interactions. You'll usually take it for 1 to 4 weeks. Next, be sure to check out these vitamin mistakes you might not know youâre making. Possible side effects include high ⦠Melatonin is a natural supplement used to help people sleep. Westbound: If you are heading west, for example, from the US to Australia, a dose is not needed for your first travel night, but you then may take it for the next 4 nights in the new time zone, after dark, 30 minutes before bedtime. Circadin tablets are used for the short-term treatment of primary insomnia, and contain the active ingredient melatonin, which is a type of hormone that is produced naturally in the body. Melatonin is mainly used to treat sleep problems in adults aged 55 or older. For instance, pregnant women are not advised to take melatonin as not enough research has been done to know if it is safe during pregnancy. Like me and many other practitioners who have researched this supplement, Dr. Breus believes melatonin is a bad answer to insomnia. It is also something that could potentially reduce libido in both sexes. However, it is very important that you avoid Bactrim and Septra, because these antibiotics are known to cause an increase in sun sensitivity and lower blood counts in people with lupus, resulting in lupus flares. But though melatonin alone can't cause overdose symptoms, be careful what medicines you're mixing together, especially with alcohol, and see your doctor before you start taking melatonin if you⦠Some people may get a headache after taking melatonin, or ⦠It varies in effectiveness from person to person, and use may lead to an accidental overdose. But even though melatonin might be safe to take in the short-term, there are still some things to consider before taking it to help you get a good nightâs rest. 'Melatonin is not a sleeping pill' That's what Dr. Michael Breus, 'The Sleep Doctor,' tells patents who inquire about this popular supplement. 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